Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Riveron M Jacob et al., A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector. Genome Biology (2014) doi:10.1186/gb-2014-15-2-r27
Zanet Stefania et al., Piroplasmosis in wildlife: Babesia and Theileria affecting free-ranging ungulates and carnivores in the Italian Alps. Parasites Vectors (2014) doi:10.1186/1756-3305-7-70
Kosawang Chatchai et al., Transcriptomic profiling to identify genes involved in Fusarium mycotoxin Deoxynivalenol and Zearalenone tolerance in the mycoparasitic fungus Clonostachys rosea Eukaryote microbial genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-55
Huang Bo et al., Genetic diversity of Plasmodium vivax population in Anhui province of China. Malaria Journal (2014) doi:10.1186/1475-2875-13-13
Yeung Yu Ka et al., The identification of mitochondrial DNA variants in glioblastoma multiforme. Acta Neuropathologica Communications (2014) doi:10.1186/2051-5960-2-1
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibson’s group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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