Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Shen Xuemei et al., Comparative genomic analysis of four representative plant growth-promoting rhizobacteria in Pseudomonas Prokaryote microbial genomics. BMC Genomics (2013) doi:10.1186/1471-2164-14-271
Varón Andrés et al., Local search for the generalized tree alignment problem Comparative genomics. BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-66
Meng Fanrong et al., Cloning and characterization of two Argonaute genes in wheat ( Triticum aestivum L.) Genetics and crop biotechnology. BMC Plant Biology (2013) doi:10.1186/1471-2229-13-18
Badaoui Bouabid et al., Impact of genetic variation and geographic distribution of porcine reproductive and respiratory syndrome virus on infectivity and pig growth Virology and prion diseases. BMC Veterinary Research (2013) doi:10.1186/1746-6148-9-58
Wu Hao et al., Diversity of endophytic fungi from roots of Panax ginseng and their saponin yield capacities Biomedical and Life Sciences. SpringerPlus (2013) doi:10.1186/2193-1801-2-107
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibson’s group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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