Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Pereira Menezes Sara et al., The pathogenesis-related protein PR-4b from Theobroma cacao presents RNase activity, Ca 2+ and Mg 2+ dependent-DNase activity and antifungal action on Moniliophthora perniciosa Plant-biotic interactions. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-161
Angermayr Andreas S et al., Exploring metabolic engineering design principles for the photosynthetic production of lactic acid by Synechocystis sp. PCC6803 Lisbeth Olsson. Biotechnology for Biofuels (2014) doi:10.1186/1754-6834-7-99
Fan Xiangyu et al., Prophage-like elements present in Mycobacterium genomes Comparative and evolutionary genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-243
Gong Xiaowei et al., Molecular investigation of bovine viral diarrhea virus infection in yaks ( Bos gruniens ) from Qinghai, China Veterinary RNA viruses. Virology Journal (2014) doi:10.1186/1743-422X-11-29
Andolfo Giuseppe et al., Defining the full tomato NB-LRR resistance gene repertoire using genomic and cDNA RenSeq Genomics and evolution. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-120
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
The materials and slides offered can not be resold or used for profit purposes. Reproduction, distribution and/or use is strictly limited to instructional purposes only and can not be used for for monetary gain or wide distribution.
Copyright 2009, OpenHelix, LLC.