Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Santangelo Luisa et al., A novel SMARCAL1 mutation associated with a mild phenotype of Schimke immuno-osseous dysplasia (SIOD) Genetics. BMC Nephrology (2014) doi:10.1186/1471-2369-15-41
Liu Wangta et al., Genome sequences characterizing five mutations in RNA polymerase and major capsid of phages ϕA318 and ϕAs51 of Vibrio alginolyticus with different burst efficiencies Prokaryote microbial genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-505
Okamoto Kenji et al., Bioconversion of xylose, hexoses and biomass to ethanol by a new isolate of the white rot basidiomycete Trametes versicolor Biomedical and Life Sciences. SpringerPlus (2014) doi:10.1186/2193-1801-3-121
Lee Chia-Ni et al., Genomic sequence of temperate phage Smp131 of Stenotrophomonas maltophilia that has similar prophages in xanthomonads Prokaryote microbial genomics. BMC Microbiology (2014) doi:10.1186/1471-2180-14-17
Deubelbeiss Martina et al., Characterization of small ruminant lentivirus A4 subtype isolates and assessment of their pathogenic potential in naturally infected goats Retroviruses. Virology Journal (2014) doi:10.1186/1743-422X-11-65
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibson’s group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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