Learn to use VBRC or Viral Bioinformatics Resource Center, a public resource that contains the most comprehensive and current genetic and molecular biology information for Category A, B, and C priority pathogens. These pathogens are regarded as possible bioterrorism threats or as emerging or re-emerging infectious diseases. This is an important resource that will allow you to quickly and efficiently retrieve useful information by becoming familiar with the searches, genomic data and gene information contained in VBRC.

You will learn:

  • how to perform similarity searches and ortholog comparisons
  • to quickly isolate genome or ortholog-specific sequence data
  • to perform DNA and amino acid alignments and homology searches
  • to create graphical representations of DNA and amino acid sequence data


This tutorial is a part of the tutorial group Microbe resources. You might find the other tutorials in the group interesting:

Complete Microbial Genomes: An extensive collection of data, resources and tools for prokaryotic genomic analysis

Viral Genomes at NCBI: Viral genome resources including single-stranded or double-stranded RNA or DNA viruses

CMR: Comprehensive Microbial Resource

Integrated Microbial Genomes (IMG): IMG is a powerful community resource for the comparative analysis and annotation of microbial genome data.

Integrated Microbial Genomes with Microbiome samples (IMG/M): IMG/M provides tools for analyzing the functional capability of microbial communities based on their metagenome sequence

UCSC Archaeal Genome Browser: Provides you with many research and analysis tools that can be used to examine the genomes of more than 50 microbial species from the domain archaea.

GenoCAD Advanced Topics: Computer-Assisted Design software for synthetic biology

GenoCAD: Computer-Assisted Design software for synthetic biology


Algorithms and Analysis : This category contains various tools that may help perform analysis of different genomics data types. This may include sequence alignment, large-scale or complex queries, motif finding, or comparative assessments.

Genome Databases (prok + viral) : Genomic databases or repositories primarily aimed at prokaryotic or viral organisms. Some may contain eukaryotic data as well.


Tip of the Week: A quick annotation of a genome: Hey, say you've got a bacterial genome you just sequenced in your spare time (hey, the way technology is going, it's not far off) and you need to do a quick and dirty annotation to get you started. Wel...

Tip of the Week: Tweaking those alignments: This week's tip introduces a nice feature and tool of the Viral Bioinformatics Resource Center (VBRC). There are a lot of great tools at the VBRC to search and analyze hundreds of viral genomes. Most, ...


Recent BioMed Central research articles citing this resource

Minkley David et al., Suffix tree searcher: exploration of common substrings in large DNA sequence sets. BMC Research Notes (2014) doi:10.1186/1756-0500-7-466

He Yong et al., Epitope mapping by random peptide phage display reveals essential residues for vaccinia extracellular enveloped virion spread. Virology Journal (2012) doi:10.1186/1743-422X-9-217

Hillary William et al., Base-By-Base version 2: single nucleotide-level analysis of whole viral genome alignments. Microbial Informatics and Experimentation (2011) doi:10.1186/2042-5783-1-2

Little S Nicole et al., Prediction of a novel RNA binding domain in crocodilepox Zimbabwe Gene 157. Microbial Informatics and Experimentation (2011) doi:10.1186/2042-5783-1-12

Tempel Sebastien et al., ModuleOrganizer: detecting modules in families of transposable elements. BMC Bioinformatics (2010) doi:10.1186/1471-2105-11-474